Abstract
SMS 201-995 was used in a 4 month-old boy presenting hypoglycemic seizures with hyperinsulinism. The dose of SMS 201-995 was rapidly increased during the first week from 10 ug/kg/day to 100 ug/kg/day, and was administrated using continuous subcutaneous infusion (CSI) during 8 months and then 3 or 2 daily subcutaneous infusion per day for 1 month. Capillary blood glucose was measured every 3 hours. Plasma insulin was evaluated twice daily on the first weeks and when blood glucose was lower than 50 mg/dl. Mean blood glucose levels was dramatically and rapidly increased by therapy, frequency of hypoglycemia was strongly reduced, blood glucose/insulin ratio increased;carbohydrate needs were reduced (0.6g/kg/day). CT Scan of the pancreas performed before therapy noticed a global increase of the volume of the gland which was no more observed after one month of therapy. Growth velocity remained in a normal range for age. Measure of plasma GH every 20 min during 5 hours had shown a normal spontaneous GH peak of 50 ng/ml. Neurologic development was normal. Others endocrine functions remained normal. Tolerance of this treatment was good excepted for transient diarrhea and vomiting during the first 2 weeks of therapy and transient moderate increase of Gamma GT. Treatment had been interrupted after one and 6 months of therapy with reccurrent hypoglycemia after 3 and 6 days respectively. 3 or 2 subcutaneous injections resulted in a worstly glycemic control than CSI therapy.
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Tauber, M., Tauber, J., Harris, A. et al. LONG TERM TREATMENT BY A LONG ACTING SOMATOSTATIN ANALOGUE (SMS 201–995) IN A 4 MONTHS BOY PRESENTING WITH PRIMARY PERMANENT HYPERINSULINISM. Pediatr Res 23, 135 (1988). https://doi.org/10.1203/00006450-198801000-00204
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DOI: https://doi.org/10.1203/00006450-198801000-00204
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