Abstract
3 children with Cushing syndgome aged 9 to 15 were treated with o,p'-DDD (LysodrenR) for 5 to 10 years. The drug lowers plasma cortisol by stimulating the microsomal enzyme system of the liver. In addition it has a direct cytotoxic effect on the adrenal cortex. Initial dosage was 25 - 45 mg/kg; maintenance dosage 15-20 mg/kg body weigth. The treatment was monitored by measuring the plasma concentration of cortisol and o,p'-DDD and its metabolit o,p'-DDE according to needs. Clinical remission was achieved in 12 weeks. Good long standing clinical results with normal plasma cortisol, diminished cortisol response to ACTH, and without clinical side effects were obtained at a plasma concentration of o,p'-DDD of 5 to 10μg/ml. Under treatment one of the patients became pregnant and delivered a healthy newborn. It is concluded that o,p'-DDD in low dosage and additional gc determination of its plasma level allow to control Cushing syndrome over long peroids of time without clinical side effects.
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Keller, E., Benecke, R., Vetter, B. et al. LONG-TERM TREATMENT OF HYPOTHALAMIC-PITUITARY CUSHING SYNDROME WITH o,p'-DDD IN LOW DOSAGE. Pediatr Res 23, 129 (1988). https://doi.org/10.1203/00006450-198801000-00170
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DOI: https://doi.org/10.1203/00006450-198801000-00170