Abstract
ABSTRACT: To investigate the morphologic correlates of decreased renal blood flow and growth arrest resulting from chronic partial ureteral obstruction in the neonate, guinea pigs were subjected to unilateral ureteral constriction within the first 2 days of life and were studied at 3 and 8 wk of age. Severity of histologic changes in the obstructed and intact contralateral kidney was assessed by light microscopy. Morphometric glomerular measurements were made using a computerized tracing device. Since contralateral nephrectomy or administration of angiotensin converting enzyme inhibitor (enalapril) result in increased blood flow to the obstructed kidney, morphologic changes were also examined in separate groups of animals subjected to these maneuvers, and were compared to appropriate controls. Ipsilateral chronic partial ureteral obstruction resulted in decreased glomerular volume (p < 0.0001) and increased glomerular crowding associated with tubular dilatation and progressive glomerular sclerosis, tubular atrophy, and interstitial fibrosis. The intact contralateral kidney underwent hypertrophy with increase in glomerular volume (p < 0.0001) and decreased glomerular density. Contralateral nephrectomy prevented the decrease in glomerular volume in the obstructed kidney and resulted in decreased glomerular density and reduced tubular atrophy at 3 wk of age. Enalapril prevented the decrease in glomerular volume at 3 wk of age, but glomerular and tubular changes progressed and were unaffected by enalapril at 8 wk. Left kidney glomerular volume was directly related to renal blood flow (r = 0.71, p < 0.05). We conclude that renal growth arrest due to chronic partial ureteral obstruction in the neonatal guinea pig is related at least in part to renal ischemia which contributes to progressive parenchymal damage. Ischemia is mediated initially by angiotensin II and by endogenous renal growth factor(s) controlled by functional renal mass.
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Chevalier, R., Sturgill, B., Jones, C. et al. Morphologic Correlates of Renal Growth Arrest in Neonatal Partial Ureteral Obstruction. Pediatr Res 21, 338–346 (1987). https://doi.org/10.1203/00006450-198704000-00004
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DOI: https://doi.org/10.1203/00006450-198704000-00004
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