Abstract
Plasma norepinephrine (PNE) is elevated in patients with conogestive heart failure (CHF) and the degree of elevation corresponds to the severity of the CHF. This study was performed to determine whether PNE returns to normal in children with CHF secondary to a left to right intracardiac shunt after repair of the defect. We measured PNE in 32 children (aged 0.1 to 13.3 years) undergoing cardiac catheterization and divided them into four groups for analysis: I) Pre-operative (op) patients with severe CHF from an intracardiac left to right shunt (N=10), II) Intracardiac left to right shunts repaired 0.3 to 4.0 years previously (N=7) who had the same degree of left to right shunting (Qp/Qs) and CHF pre-op as Group I, but post-op were asymptomatic on no medications, III) Pre-op patients with cyanotic heart disease and no CHF (N=7), and IV) Cyanotic heart disease (N=8), repaired 0.7 to 7.0 years previously.
For group II, there was an inverse relationship between the LN PNE and time interval since repair (R=−0.71). We conclude that PNE is markedly elevated in patients with severe CHF but returns to normal in a log linear fashion after repair of intracardiac left to right shunts and resolution of CHF. In contrast, PNE in cyanotic heart disease is normal pre- and post-operatively.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ross, R., Daniels, S., Schwartz, D. et al. NORMALIZATION OF PLASMA NOREPINEPHRINE FOLLOWING REPAIR OF INTRACARDIAC LEFT TO RIGHT SHUNTS. Pediatr Res 21 (Suppl 4), 194 (1987). https://doi.org/10.1203/00006450-198704010-00165
Issue Date:
DOI: https://doi.org/10.1203/00006450-198704010-00165