Abstract
The histological studies and clinical histories of 60 patients with Hemolytic Uremic Syndrome (HUS) followed up at the Children's Hospital of Cordoba City (Argentine) between 1965-1982 were reviewed. Histological studies were performed with biopsy specimens in 54 cases and with necropsy specimens in the other 6. In all cases the studies were performed during the first four weeks of the disease. In 47 cases (78,3%) typical thrombotic microangiopatic lesions (MATR) were found, while in the another 13 cases (21,6%) the lesions were inespecific. The lesions were classified into threee groups: TYPE I: those cases with focal MATR or inespecific lesions (41,7%); TYPE II: those cases with difusse MATR (36,6%) and TYPE III: those cases with difusse MATR complicated with cortical necrosis or vascular damage (21,6%). Fourty three patients were re-examined with clinical and laborattories tests during 1983. Twenty three of them were cured while the another twenty showed some renal secuelae. Thirteen had proteinuria, two arterial hypertension and five chronic renal failure. Healing was observed in 65% of the patients with lesions TYPE I, in 34,7 of the patients with lesions TYPE II and in 0% of the patients with lesions TYPE III. The patients with lesions type I or II only showed proteinuria as renal secuelae, but those with lesions type III developed proteinuria, arterial hypertension and or chronic renal failure. We conclude that the present histopatological classification of the early renal lesions are useful in order to predict renal damage in late period of the disease. Chronic renal failure depends on the presence of cortical necrosis or vascular damage.
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Martini, R., Gallo, G. HEMOLYTIC UREMIC SYNDROME: EARLY RENAL LESIONS AND LATE PROGNOSIS. Pediatr Res 22, 370 (1987). https://doi.org/10.1203/00006450-198709000-00041
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DOI: https://doi.org/10.1203/00006450-198709000-00041