Abstract
Patients post HUS develop high blood pressure in long term follow up. In a previous paper it was shown that hypertensive (H) patients post HUS did not increase their aKK after a diuretic stimuli as the normotensive (N) did aKK and tKK were evaluated in these patients to examine if the different response is due to a lack of secretion or a failure in the activation. Both KK were evaluated in 24 patients post HUS (10H and 14N) before and after 10 days of administration of lmg/kg/day of hidroclorothizide+ amiloride, with S 2266 substrate. Results, are exressed in nkat/day or /mg creatininuria. per day: N: aKK pro 3.4 ± 0.7 - post 11.2 ± 1.6 (p<0.001), tKK pro 11.2 ± 2.1 - post 34.4 ± 5.5 (p<0.001). H: aKK pre 3.2 ± 0.5 - post 5.5 ± 0.8 (p<0.01), tKK pre 10.6 ± 1.5 - post 16.9 ± 2.7 (p<0.01) Per mg Cr: N: aKK pre 6.4 ± 1.8 post 19.4 ± 3.5 (p<0.005), tKK pre 20.5 ± 5.5 - post 60 ± 11.5 (p<0.001); H: aKK pre 8.7 + 1.7 - post 15 + 3 (p<0.005) tKK pre 31.1 6.1 - post 43.8 ± 7 (p NS). There was no difference of aKK or tKK por day or per mg Cr. between both group before stimulation. After the stimuli aKK and tKK/day were significantly lower in H (p<0.005 and p<0.01). aKK/mg Cr increased after the stimuli in both groups, but winle N increased their tKK/mg Cr (p<0.001), H did not. These data indicate that hypertensive children post HUS cio not increase their tKK probably due to a lack of secretion in relation to an alteration in the distal tubular mass.
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Grunfeld, B., Simolo, R., Gimenez, M. et al. ACTIVE AND TOTAL URINARY KALLIRREIN (aKK - tKK) IN PATINES POGT HEMOLYTIC UREMIC SYNDROME (HUS). Pediatr Res 22, 369 (1987). https://doi.org/10.1203/00006450-198709000-00034
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DOI: https://doi.org/10.1203/00006450-198709000-00034