Abstract
The long term efficiency of bone-marrow transplantation in children has to be judged both on the survival rate and on the importance of potential side effects. Alteration of growth pattern and of the gonadal and thyroid functions has been reported. 13 patients, 7 M and 6 F, aged 4y9m to 21y8m (mean = 11y2m) have been examined 9m to 3y5m (mean = 1y4m) after bone-marrow transplantation (9 allo, 4 auto) for the treatment of ALL in 6, lymphoma in 2, AHL in 2, aplastic anaemia in 2 and Chediak-Higashi in 1. Growth velocity was found below the 5th percentile in 9 with height below the 3th percentile in 4. It was a trend to find lower growth velocity among patients with allotransplantation and TBI. Evidences of gonadal dysfunction were found in 5 cases. The 8 other patients were too youg to allow conclusion. The somatropin (GH) secretion judged on the phamacological responses was fully normal in 6, deficient in 3 and border line in 4 patients. 9 of the 10 patients with decreased responses were explored for the nocturnal GH secretion pattern. Only 2 have a normal secretion, 4 have a decreased peak and 3 decreased peak and integrated secretion. The patients given total body irradiation tend to have a lower GH secretion. Such changes require a mandatory endocrinological follow-up for early diagnosis and treatment if necessary to allow a normal subsequent physical development.
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Leheup, B., Bordigoni, P., Dousset, B. et al. GONADAL AND SOMATROPIC FUNCTIONS OF 13 CHILDREN AFTER BONE-MARROW TRANSPLANTATION. Pediatr Res 20, 1204 (1986). https://doi.org/10.1203/00006450-198611000-00186
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DOI: https://doi.org/10.1203/00006450-198611000-00186