Abstract
Basic Fibroblast growth factor (FGF) is a polypeptide of 17.000 PM, isolated from various bovine and human tissues. This factor has a strong mitogenic activity and maintains differenciation of mesodermic cells in vitro, but its physiological role remains unknown. We used a radioimmunoassay (RIA) developped by Guillemin et al. Using antibodies raised against a synthetic replicate of |Tyr10| FGF (1-10). Our RIA intraassay and interassay coefficients of variation were 14% and 7% respectively. 83 children, 44 boys and 39 girls aged from 1 year 1 month to 15 years 10 months (m : 6 years 6 months) were studied. FGF mean value was 20,01 ± 6,18 pmol|ml. A great disparity of individual values was found. No significative difference was found between boys (18,76 ± 6,28 pmol/ml) and girls (20,87 ± 5,84 pmol/ml). FGF values did not correlated with chronological age, but analysis of the results showed a slightly increase of FGF values with a maximum peak in prepubertal stage (10-12 years) followed by a slow decrease in pubertal children (12-16 years). We had previously studied 135 adults men and women. Adult FGF levels were lower than in children (m : 18,34 ± 4,44 pmol/ml, p<0,05) and no sex difference was found. Mean FGF value in blood cord of 8 neonates boys was lower than in H.6 years children (m : 15,58 ± 3,83 pmol/ml, p < 0,05). This preliminary study suggests that seric FGF determination could be a way to investigate the role of FGF in vivo and particularly in growth and development.
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Tauber, M., Barbe, P., Gauthier, T. et al. SERUM LEVELS OF FIBROBLAST GROWTH FACTOR IN CHILDHOOD AND ADOLESCENCE: A PRELIMINARY STUDY. Pediatr Res 20, 1183 (1986). https://doi.org/10.1203/00006450-198611000-00060
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DOI: https://doi.org/10.1203/00006450-198611000-00060