Abstract
1./A retrospective analysis of 211 children with leukaemia was performed. Association of major congenital malformations and the mean survival times were recorded. 17 major anomalies/13 in children with acute lymphoblastic leukaemia/ALL/ and 4 with acute myeloblastic leukaemia/AML/were found: 5 of them were diagnosed as Down's syndrome.The association of malformations with ALL was more frequent in girls/11.4 per cent/ than in boys/5.4 per cent/. When compared with age,- and sex-matched control children treated by the same approach,no difference in prognosis, complete remission and mean survival time could be found. Remission rate in the cases with Down's syndrome was 50 per cent, while it was 100 per cent in the other patients with malformations.
2./ 55 minor anomalies in 100 children with malignancies/51 with leukaemia and 49 with different solid tumours/were analyzed. The frequency of minor anomalies in the patients' group/2.12 anomalies/person/ was significantly higher than in healthy controls/0.94 anomalies/person/. Although some types of minor anomalies occurred more frequently in children with malignancies, no tumour-specific association could be demonstrated.
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Fekete, G., Réthy, L., Kardos, G. et al. 67 ASSOCIATION OF CONGENITAL MALFORMATIONS AND MINOR ANOMALIES IN CHILDREN WITH MALIGNANCIES. Pediatr Res 20, 1045 (1986). https://doi.org/10.1203/00006450-198610000-00121
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DOI: https://doi.org/10.1203/00006450-198610000-00121