Abstract
Recovery of lung function with time after challenge with histamine was studied in 45 asthmatic children (14 girls and 31 boys) aged 8 to 15 years. The children were allergic to house dust mite and had an increased bronchial reactivity to histamine. Lung function tests and histamine challenge were performed under standardized conditions. Baseline FEV1, the provocation concentration producing a 20% fall in FEV1 (PC20) for histamine, the fall in FEV^ after inhaling histamine and age were compared with time of complete recovery of FEV1. A signifj cant correlation was found between PC20 (histamine) and time of complete recovery (p=0.023). No significant correlation was found between total recovery time and the other parameters. Baseline FEV1 was compared with PC20 for histamine. A significant correlation could be demonstrated between pretest bronchial obstruction (baseline FEV1) and the PC20 for histamine (p=0.028). FEV1 recovered within 75 min. to pretest values in all but two children. Conclusions: The response to histamine is related with pretest bronchial obstruction. In a few children recovery from histamine challenge is prolonged. In these children further provocation test on the same day should be avoided. The recovery time is related with the dose of histamine administered.
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Gerritsen, J., Koeter, G., Van Aalderen, W. et al. 51 RECOVERY OF LUNG FUNCTION FROM HISTAMINE CHALLENGE IN ASTHMATIC CHILDREN. Pediatr Res 20, 1042 (1986). https://doi.org/10.1203/00006450-198610000-00105
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DOI: https://doi.org/10.1203/00006450-198610000-00105