Abstract
A multicenter study of the relative safety and immunogenicity of the purified heat-sized Hib polysaccharide (PRP) and conjugate (PRP-D) vaccines was conducted in 475 children 16-24 months of age. No serious reactions occurred in either group. Except for fewer febrile reactions in the PRP-D group (p<.05), other reactions were similar for both vaccines.
Immune responses were measured by KIA (ug)ml and are summarized below:
Although PRP is soon to be licensed for use in older children, PRP-D is at least as safe and significantly more immunogenic.
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Berk-Owitz, C., Zahradnik, J., Hendley, J. et al. 512 HEMOPHILUS INFLUENZAE TYPE B(HIB) POLYSACCHARIDE VACCINE: SAFETY AND IMMUNOGENICITY OF PRP AND PRP-D CONJUGATE VACCINES IN CHILDREN 16–24 MONTHS. Pediatr Res 19, 196 (1985). https://doi.org/10.1203/00006450-198504000-00542
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DOI: https://doi.org/10.1203/00006450-198504000-00542