Abstract
We investigated whether puberty might be characterized by the ability to secrete gonadotropins (Gn) in response to LHRH infusion after the readily releasable pool of Gn is exhausted. We studied 14 girls and 16 boys ages (CA) 6 to 19 and bone ages (BA) 8 to 14. A 100 μg bolus (B) of LHRH was followed 1 hour later by an infusion (I) of 100 μg LHRH over 2 hours. 6 girls with precocious puberty and 7 boys with delayed puberty had responses indistinguishable from controls (p>.05, see table). 3 boys and 1 girl, CA 16–19, BA 13.5 to 15 with Gn deficiency had an area under the curve that was clearly different from controls. In all subjects a comparable amount of gonadotropin was secreted during I as following B (r=>.95, p<.001 for both LH and FSH).
We conclude from these data that (1) the slowly releasable gonadotropin pool is as large as the readily releasable gonadotropin pool in both clinically prepubertal and pubertal subjects; (2) for most diagnostic purposes an infusion of LHRH has no advantage over bolus administration.
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Wu Richards, G., Cavallo, A., Smith, E. et al. 486 DEMONSTRATION OF 2 POOLS OF GONADOTROPINS IN PERIPU BERTAL CHILDREN BY A 2 PHASE LHRH TEST. Pediatr Res 19, 191 (1985). https://doi.org/10.1203/00006450-198504000-00516
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DOI: https://doi.org/10.1203/00006450-198504000-00516