Abstract
A potential for T4 or T3 therapy in prevention of IRDS of the newborn has been recently proposed (J.C.I.74,898,1984). We explored the dose-responsiveness of F/M GLU-GLY metabolism to M administration of T4 or T3. T4 (150 or 250μg/kg), T3 (75,125,175 or 225μg/kg) or vehicle were administered IM on d 25 & 26 of pregnancy to rabbit doe. F & M plasma GLU, insulin (I), free T4 (FT4) & T3 concentration, cardiac (Ca) & hepatic (H) GLY content were quantitated on d 27. All data X±SEM (P*<0.05 vs control (c)). n = No. of litters. UD = undetectable.
M GLU, M & F I were similar in all groups.
Conclusions:1) T4 or T3 crosses the rabbit placenta from M in a dose dependent manner. 2) M T4 or T3 Rx causes F but not M hyperglycemia without change in I 3) T4 or T3 deplete F Ca & H GLY. 4) M H but not Ca GLY is depleted with higher dose of T3.
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Devaskar, U., Church, J., Chechani, V. et al. 444 EFFECT OF T4 OR T3 ON MATERNAL (M)-FETAL (F) GLUCOSE (GLU)-GLYCOGEN (GLY) METABOLISM. Pediatr Res 19, 184 (1985). https://doi.org/10.1203/00006450-198504000-00474
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DOI: https://doi.org/10.1203/00006450-198504000-00474