Abstract
VIP is found in the heart and increases coronary blood flow (BF) in anesthetized dogs. BF was measured (radioactive microspheres) in 6 - 8 week old piglets during vehicle infusion and at 10 min of VIP (1μg/kg/min, iv; plasma VIP of 9±2ng/ml). VIP increased heart rate (228±14 vs 136±8* beats/min), reduced systemic pressure (64±5 vs 92±3*mmHg), reduced LA pressure (2±1 vs 7±2*mmHg), while CO was unchanged (276±30 vs 261±20ml/min/kg). There was no increase in LV, RV or atrial BF after 10 min of VIP infusion. In addition, regional vascular resistance was unchanged (table). VIP reduced stroke volume (1.3±0.2 vs 2.0±0.2* ml/min/kg/beat), stroke work (83±18 vs 182±22* units) and the LV endo/epi BF ratio (1.03±0.04 vs 1.23±0.06*). (*p<0.05)
Thus, VIP in awake piglets reduces stroke work, stroke volume, does not increase and causes a maldistribution in LV BF.
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Einzig, S., Lorenz, E., Rysavy, J. et al. 363 EFFECT OF VASOACTIVE INTESTINAL PEPTIDE(VIP) ON REGIONAL CARDIAC FLOW IN THE AWAKE PIGLET. Pediatr Res 19, 171 (1985). https://doi.org/10.1203/00006450-198504000-00393
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DOI: https://doi.org/10.1203/00006450-198504000-00393