Abstract
Infants with chronic lung disease often develop rickets secondary to prolonged lasix (L) treatment. We studied the effect of CT on the hypercalciuric response to L in 11 young adult rats (Wt 259±1.1 gm, M±SE). The rats were fed Purina rat chow and received water ad lib. At the end of a 15 day control period, urine was collected for 72 hrs. The rats were then divided into 2 groups: Group I (n=5) received 15 mg/kg/d of L IP and Group II (n=6) received 20 mg/kg/d of CT IP for 15 d, at the end of which a 72 hr urine collection was performed. Following this all rats received both drugs at the above dosage and a third 72 hr urine collection was done at the end of a 15 d treatment period. Each urine collection was analyzed for Ca concentration. Urinary Ca excretion data (mg/kg/d) are displayed below. We conclude that administration of L produces a 50% increase in urinary Ca excretion compared to control. However, the combination of L and CT caused a 24% reduction in urinary Ca excretion when compared with L alone. Urinary Ca excretion with CT alone was not significantly different than control. These data support the use of both CT and L therapy in infants with chronic lung disease when diuretic therapy is needed.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Butler, C., Ehrenkranz, R. & Gross, I. 349 THE EFFECT OF CHLOROTHIAZIDE (CT) ON LAS IX-INDUCED HYPERCALCIURIA. Pediatr Res 19, 169 (1985). https://doi.org/10.1203/00006450-198504000-00379
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-00379