Abstract
A potential for B+T3 therapy in prevention of IRDS of the newborn has been recently proposed (J.C.I. 74,898, 1984). Some of the major growth and metabolic effects of B and/or T3 therapy on the M and F were determined. B (85 μg/kg), T3 (175 μg/kg), B+T3 (85 and 175 μg/kg) or the vehicle were administered I.M. on d 25 and 26 of pregnancy to rabbit doe. F wt, F and M plasma GLU, insulin (I) and T3 concentration, F and M cardiac (Ca) and hepatic (H) GLY content were quantitated on d 27. All data X±SEM (*P <0.05 vs control (C)). n = No. of litters.
Conclusions: 1) Runting effect of B is prevented when administered with T3 2) Major differences in M and F are noted: (a) T3 and/or B cause F but not M hyperglycemia (b) T3 and/or B deplete F but not M Ca GLY (c) B deplete F but increase M H GLY and (d) T3 deplete M and F H GLY.
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Devaskar, U., Church, J., Chechani, V. et al. 254 EFFECT OF BETAMETHASONE (B), TRIIODOTHYRONINE (T3) OR B+T3 ON MATERNAL (M) AND FETAL (F) GLUCOSE (GLU)- GLYCOGEN (GLY) METABOLISM. Pediatr Res 19, 153 (1985). https://doi.org/10.1203/00006450-198504000-00284
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DOI: https://doi.org/10.1203/00006450-198504000-00284