Abstract
Gas exchange impairment occuring with intralipid (IL) infusion has been related to disturbed pulmonary microcirculation due to lipid globules, altered red cells(RBC) membrane composition and enhanced RBC and platelet aggregation. Hemorheological effects of IL were studied using a cone-plate viscometer (whole blood and plasma viscosity), filtration method (filtrability of RBC), rheoscope (RBC deformability), and light transmission (RBC aggregation). IL (0.15 g/kg/h) was infused in 10 preterm and 10 full term infants. Blood samples were studied prior to and at the end of insufion (4 h). None of the hemorheological methods showed abnormal results. In vitro RBC from 10 preterm, 10 term infants and 10 adults were suspended in plasma and buffer and were studied after 3 and 6 h of incubation with IL at concentrations of 0, 1, 2, 4 and 8 mg/ml of RBC. Whole blood and plasma viscosity and RBC deformability were not altered by IL. However, RBC aggregation decreased markedly with increasing IL concentration. RBC filtration was significantly impaired in the presence of IL both in plasma and in buffer. RBC were also incubated with IL, then washed and resuspended in IL free plasma and buffer before filtration. These cell showed normal filtration rate. We conclude that hemorheological alterations occuring at high IL concentrations are not the result of altered RBC deformability and aggregation but rather due to plasma hyperlipemia causing obstruction of filter pores and possibly of capillaries.
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Sengespeik, H., Güntner, M., Raz, D. et al. HEMORHEOLOGICAL EFFECTS OF INTRALIPID. Pediatr Res 19, 1131 (1985). https://doi.org/10.1203/00006450-198510000-00335
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DOI: https://doi.org/10.1203/00006450-198510000-00335