Abstract
In an attempt to clarify the risk factors involved in the decreased survival of the red cells of the neonate,a comparison of erythrocytes in cord blood and those in 4 day olds was performed.The following deter minations were carried out:Hb,Htc,MCV,electron spin resonance spectros-copy of nitroxide radical Mal-6,age dependent and oxygen scavenger erythrocyte enzyme activities G-6-PD,PK,GPI,GSH-Px,SOD and CAT;F and A1 Hb percentages.The findings were as follows:l)lower reduction kinetics of the specific -SH reagent Mal-6 in the cord blood.This finding suggests limited availability of reducing agent in cord blood or decreased membrane permeability there to.2)Normalization of Mal-6 kinetics after resuspending cord blood red cells in the plasma of 4 day old infants. It is evident that significant modifications of the newborn's erythrocytes are induced by plasma factors.3)Increase in the mean oxygen scavenger activity GSH-Px from birth to 4th day of life.This is most likely due to the disappearance from the circulation of the red cells less resistant to oxidative stress.4)Increase in F Hb during the first 4 days of life.
The results of the present investigation demonstrate that a certain number of erythrocytes viable uder intrauterine conditions,are removed from circulation after birth.
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Talluri, B., Buonocore, G., Martini, G. et al. RISK FACTORS FOR ERYTHROCYTES DURING FIRST DAYS OF LIFE. Pediatr Res 19, 1130 (1985). https://doi.org/10.1203/00006450-198510000-00329
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DOI: https://doi.org/10.1203/00006450-198510000-00329