Abstract
ABSTRACT: Concentrations of IgG1, IgG2, and total IgG were measured by a solid phase radioimmunoassay in sera from 36 healthy adults and 114 healthy children. As expected, IgG2 and total IgG had a positive correlation with age in children. In addition to age, several other factors were associated with significant differences in serum subclass concentrations. Female children had higher concentrations of IgG1 than males, and black subjects had significantly higher concentrations of IgG1, IgG2, and total IgG than whites. Although Km(1) and Gm(23) immunoglobulin allotypes had no relation to subclass concentrations when tested as single factors, the Km(1) allotype interacted significantly with race so that Km(1)-positive black children had higher IgG2 concentrations than other subjects. Our findings may explain, in part, recent observations of an association of the Km(1) allotype with altered immune responses of blacks to certain vaccines containing bacterial polysaccharides. In addition, our data indicate the need to control factors such as sex, race, and allotype in studies of subclass concentrations or immune responses.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shackelford, P., Granoff, D., Nahm, M. et al. Relation of Age, Race, and Allotype to Immunoglobulin Subclass Concentrations. Pediatr Res 19, 846–849 (1985). https://doi.org/10.1203/00006450-198508000-00014
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198508000-00014
This article is cited by
-
Fc receptors and the diversity of antibody responses to HIV infection and vaccination
Genes & Immunity (2022)
-
Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis
European Journal of Pediatrics (1994)