Abstract
BPD remains a significant problem in the premature infant. Mortality associated with Stage IV BPD is 39% (J. Pediat. 816, 1979). The objective of this retrospective study was to determine factors associated with fatal outcome in infants with Stage IV BPD (radiographic) and a prolonged hospital course >100 days.
The study comprised 24 premature infants; 11 died and 13 survived (controls). No differences between the groups were noted as regards birthweight, gestational age, ventilator requirement, radiographic changes and medications (Digoxin, aldactazide), except for Lasix which was used twice as frequently in the group who died vs controls (p<.001). Four striking differences were noted between the groups (Table).
The data define significant alterations in blood pressure, serum chloride, acid base status, and head growth. The findings are important for two reasons. First, they define factors that may be important in the genesis of a poor outcome in such infants, and second, they suggest that close monitoring of these parameters and correction when possible, may improve prognosis.
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Perlman, J., Moore, V., Siegel, M. et al. 1813 Factors Associated with Fatal Outcome in Premature Infants with Prolonged Bronchopulmonary Dysplasia (BPD). Pediatr Res 19, 413 (1985). https://doi.org/10.1203/00006450-198504000-01831
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DOI: https://doi.org/10.1203/00006450-198504000-01831