Abstract
The pathophysiology for increased incidence of hyaline membrane disease seen in infants of diabetic mothers is controversial. The effects of hyperglycemia on lung tissue PC and DSPC content was studied using rabbits. The femoral vein was catheterized in pregnant rabbits on 26th day of gestation. Hyperglycemia was induced by continuous infusion of D30 0.3%saline(Gr1) over a 46–48 hour period. The two control groups consisted of 0.9%saline infusion(Gr2)and Sham operated(Gr3). On 28th day of gestation C-hysterectomy was performed. Lungs were removed and analysed for total phospholipid(TPL), PC and DSPC content. Serum insulin and glucose were determined on doe's and fetal blood. Data on 10 rabbit does in Gr1, 7rabbit does in Gr2 and 9rabbit does in Gr3 are available. Both serum glucose and insulin were higher in does and fetuses in Gr1 compared to Gr2 and Gr3. As a % of TPL,PC and DSPC were not different in any of the 3groups. There was no difference between male(M)and female (F)fetuses in relation to the different treatment groups.
These data suggest that hyperglycemia induced by the infusion of high concentration of dextrose for about 6% of gestational time does not alter lung tissue PC and DSPC content in fetal rabbit in vivo at 26–28 days of gestation.
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Patel, D., Rhodes, P., D'Cruz, C. et al. 1809 LUNG TISSUE PHOSPHATIDYL CHOLINE(PC)AND DISATURATED PC(DSPC) IN HYPERGLYCEMIC FETAL RABBITS IN VIVO. Pediatr Res 19, 412 (1985). https://doi.org/10.1203/00006450-198504000-01827
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DOI: https://doi.org/10.1203/00006450-198504000-01827