Abstract
The relation between inflow volume (IV), peritoneal clearance (PC) and development of hernias is not well established in pediatric pts. We therefore performed 73 PC studies in 40 CAPD/CCPD pts. aged 12.4 ± 5.4 (SD) yrs. After a 2 hr dwell with different IV a peritoneal fluid sample was obtained and clearances (C) of creatinine (Cr), urea-N (U-N), potassium (K), uric acid (UA) and phosphorus (P) were obtained. According to the IV, the pts. were placed in 3 different groups (A=20-34.9, 8=35-44.9, C=45-66 cc/kg). In groups A, B, C the mean PCCr corrected for 70 kg BW were 9.4 ± 3.6, 11.1 ± 3.8, 14.4 ± 4.6 ml/rain respectively (A vs B p=NS, B vs C p<0.05, A vs C p<0.005). PCU-N were 1.9 ± 2.8 (A), 14.8 ± 3.5 (B) and 19.5 ± 3.5 (C) ml/min/70 kg respectively (A vs B p<0.005, B vs C p<0.001, A vs c p<0.001). PCK and P were significantly higher with the increased volumes (K: 11.3 ± 2.8, 13.8 ± 3.2, 18.3 ±2.2 ml/min/70 kg p<0.05, <0.001, <0.001). P: 8.7 ± 2.6, 8.9 ± 3.9, 12.0 ± 3.1 ml/min/70 kg, p=NS, <0.05, <0.05). Only the PCUA failed to increase with increased volumes (8.7 ± 2.5, 9.0 ± 2.4, 11.8 ± 3.7 ral/min/70 kg p=NS). Seventeen of the 40 pts developed 27 inguinal, ventral or umbilical hernias after 16.5 ± 11.7 mos of dialysis with an IV ranging between 25.6 and 48.4cc/kg (mean 37.3 ± 5.9). These data indicate that maximal dialysate volumes provide greater C. The IV does not per se effect hernia development. Pts should be carefully evaluated for hernias at the time of initiation of PD.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Von Lilien, T., Salusky, I., Alliapoulos, J. et al. 1651 THE EFFECT OF DIALYSATE VOLUME ON PERITONEAL CLERANCES AND ON THE DEVELOPMENT OF HERNIAS IN CHILDREN TREATED WITH CAPD/CCPD. Pediatr Res 19, 386 (1985). https://doi.org/10.1203/00006450-198504000-01675
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-01675