Abstract
Children, aged 7 mos. to 19 yrs. with culture-proven, acute, uncomplicated lower UTI, were randomized to receive Amoxicillin as either single dose (40 mg/kg; max. 500 mg/dose) four day (40 mg/kg/day; max. 500 mg/dose) or ten day (40 mg/kg/day; max. 500mg/dose therapy. Twenty-eight patients completed the study. Urine cultures were performed X2 on entrance to the study. Follow-up cultures were taken approx. 48 hrs. after initiation of therapy and 3-5 days after completion of therapy. Sedimentation rate (ESR) and C-reactive protein (CRP) were obtained prior to therapy. Pre-therapy organisms were E. coli in 63%, 100% and 85% respectively of the single dose, four day and ten day therapy groups. The 11 patients treated with single-dose therapy and 10 patients treated for four days had cure rates (55% and 70% respectively), that did not differ significantly from cure rates in the 7 patients receiving ten day therapy (71%) or from each other when three way analysis is applied to the cure rates. Relapse rates (45% and 30%) and induction of resistant organisms (9% and 0%) in the single-dose and four day therapy groups did not differ signficantly from that of the ten day group. ESR (24 ±4 mm/hr, n=23) and CRP (0.81±0.08 mg/dl, n=27) did not corre correlate with treatment outcome. The results of this study suggest that short-term antibiotic therapy of uncomplicated lower UTI's in children is effective.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johnson, V., Khan, A., Tongson, A. et al. 1608 URINARY TRACT INFECTIONS (UTI) IN CHILDHOOD: A RANDOMIZED TRIAL OF SHORT-TERM VS. CONVENTIONAL THERAPY. Pediatr Res 19, 378 (1985). https://doi.org/10.1203/00006450-198504000-01632
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-01632