Abstract
We previously reported that blood in the lateral ventricle of the newborn dog acutely impairs cerebral blood flow (CBF). The current study sought to clarify the mechanism for these changes in imperfusion. For the first two groups of puppies autologous blood was infused into the lateral ventricle to maintain an intraventricular pressure (IVP) of approximately 50 mmHg for 20 minutes; CBF was determined at the end of the infusion in one of these groups and following return of the IVP to near baseline level in the other (mean time-25 rain). For a third group of puppies normal saline (NS) was infused for 20 min. prior to CBF determination and a fourth group served as controls. CBF was measured by [14C] iodoantipyrine autoradiography.
The transient decrease in CBF following blood infusion appears to be due to the elevated IVP and reduced perfusion pressure. The reason mean arterial blood pressure (MABP) did not increase to maintain CBF following blood infusion as seen following NS infusion is not clear.
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Batton, D., Nardis, E. & Maisels, M. 1336 INTRAVENTRICULAR BLOOD AND CEREBRAL PERFUSION IN NEWBORN DOGS. Pediatr Res 19, 333 (1985). https://doi.org/10.1203/00006450-198504000-01360
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DOI: https://doi.org/10.1203/00006450-198504000-01360