Abstract
Infants of diabetic mothers have a higher incidence of neonatal hypocalcemia and hypomagnesemia. Decreased BMC has been reported in diabetic patients, with bone mineralization of IDM has not been; systematically evaluated. The present study was done to test the hypothesis that decreased neonatal BMC in IDMs is correlated with poor control of diabetes during pregnancy & with the development of neonatal hypocalcemia. 54 fullterm IDMs & 55 normal fullterm controls, infants of non-diabetic mothers were prospectively studied. Mothers of IDMs were classified prospectively in 3 groups: group 1-strict control of diabetes from the first trimester: group 2-customary control from the first trimester: group 1 & 2 were randomized; group 3-late entry (after first trimester) in the study. Maternal BMC was measured prior to delivery. Infant serum calcium was measured at age 24 & 72 hours, & infant BMC at age 3 days. Multiple regression analysis shows that: 1) infant's BMC is not correlated with maternal BMC, neonatal hypoglycemia, neonatal hypocalcemia & infant weight percentile; 2) IDMs from group 2 & 3 had significantly lower BMC than IDMs from group I (p<0.02); 3) IDMs from group 1 & controls had similar BMC. It appears that decreased BMC is observed in IDMs & may be prevented by strict control of diabetes during pregnancy. Decreased BMC in IDMs does not seem to play a role in the pathogenesis of neonatal hypocalcemia. We speculate that decreased BMC in IDMs might be in the diabetic pregnancy inappropriate calcium supply through the placenta.
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Mimouni, F., Brazerol, W., Steichen, J. et al. 1238 BONE MINERAL CONTENT (BMC) OF INFANTS OF DIABETIC MOTHERS (IDMS). Pediatr Res 19, 317 (1985). https://doi.org/10.1203/00006450-198504000-01268
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DOI: https://doi.org/10.1203/00006450-198504000-01268