Abstract
Cryoprecipitates have been postulated to play a role in the pathogenesis of several autoimmune diseases. To investigate the presence of cryoprecipitates in Kawasaki syndrome (KS), we studied sera from ten children with KS for the presence of cryoprecipitates, concentration of 63, C4, and Factor B, and soluble immune complexes by the Ciq binding assay. Cryoprecipitates were present in seven of ten children. The protein concentration of the cryoprecipitate was 82.5 ± 19.9 ug/ml. The immunoglobulins within the cryoprecipitate consisted primarily of IgG and IgM; no complement components could be detected. In addition, soluble immune complexes were detected in the serum of all ten children studied at a concentration of 130.9 ± 16.1 ug/ml. Despite the presence of soluble immune complexes and cryoglobulins, there was no relationship between immune complexes and complement levels. In limited serial studies, the concentration of protein within the cryoprecipitates diminished in parallel with clinical improvement.
We conclude: 1) cryoprecipitates were frequently found in the serum of children with KS; 2) the immunoglobulin within the cryoprecipitates was predominantly IgG and IgM; 3) the concentration of the cryoprecipitates tends to parallel the clinical activity, and 4) soluble immune complexes were present in all children with KS.
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Herold, B., Davis, A., Shulman, S. et al. 982 CRYOPRECIPHATES, IMMUNE COMPLEXES, AND COMPLEMENT LEVELS IN KAWASAKI SYNDROME. Pediatr Res 19, 274 (1985). https://doi.org/10.1203/00006450-198504000-01012
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DOI: https://doi.org/10.1203/00006450-198504000-01012