Abstract
Carbamazepine (Tegretol),a widely used anticonvulsant, is known to be associated with various hematologic toxicities including thrombocytopenia.Platelet associated immune globulin (PAIg) was measured in two children who were taking carbamazepine.PAIgG and PAIgM were significantly elevated in a patient with pancytopenia which developed 2 months after intitiation of the drug.Platelet counts and PAIg levels returned toward normal within 3 weeks of drug stoppage.PAIg was also found to be elevated in a second patient who had been on carbamazepine for 4 months and in whom there was no hematologic abnormality.There was no evidence of underlying autoimmune disorder in either patient.
Elevated PAIg in patients on carbamazepine has not been reported. It appears that thrombocytopenia seen with carbamazepine adminstration may in some instances be due to production of specific antibody.Alternatively,the drug may induce a change in platelet membrane which allows adsorption of Ig.Investigation of this phenomenon could lead to a better understanding of the significance of PAIg in thrombocytopenia.
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Miller, S., Gowda, V., McFall, P. et al. PLATELET ASSOCIATED IMMUNE GLOBULINS IN PATIENTS TAKING CARBAMAZEPINE. Pediatr Res 18 (Suppl 4), 245 (1984). https://doi.org/10.1203/00006450-198404001-00913
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DOI: https://doi.org/10.1203/00006450-198404001-00913