Abstract
Platelet dysfunction in the pathogenesis of intraventricular hemorrhage (IVH) is controversial. Platelet function testing using platelet rich plasma (PRP) was performed on 56 premature infants (26-32 weeks gestational age, mean birth weight 1156 gm) using aggregometry and a viscoelastic method. The Sonoclot® measures viscoelastic changes in plasma after recalcification; PRP has a characteristic Sonoclot® curve consisting of a lag time, primary wave, shoulder, secondary wave and downward tertiary wave. The secondary and tertiary waves reflect platelet incorporation into the clot and clot retraction. Normal adult PRP Sonoclot® values for the lag time, slopes and shoulder to peak (S-P) interval have been reported.
Of the infants studied, 22 (39%) had some degree of IVH by ultrasonography. Platelet function as maximal aggregation of PRP (5μM ADP) in these infants did not differ significantly from that of 34 infants without IVH (x̄±SEM): IVH=52.8%±4.7 vs no IVH=52.0%±3.8 on day one and IVH=42.7%±4.7 vs no IVH=48.5%±3.4 on day three. Sonoclot® values on day one were (x̄±SEM):
The groups did not significantly differ in any Sonoclot parameter and all of the mean values in both groups were similar to reported normal adult values.
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Courtney, J., Kolni, H. & Gross, J. PLATELET FUNCTION IN PREMATURE INFANTS WITH INTRAVENTRICULAR HEMORRHAGE. Pediatr Res 18 (Suppl 4), 239 (1984). https://doi.org/10.1203/00006450-198404001-00874
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DOI: https://doi.org/10.1203/00006450-198404001-00874