Abstract
The rapid portal transport and hepatic oxidation of MCT point to their utilization as a readily available source of energy. This is supported by observations showing decreased fat storage in MCT fed rats. However the composition of adipose tissue (ADIP) has not been studied. The fatty acid (FA) pattern of ADIP from infants operated on for inguinal hernia was determined by gas chromatography using the internal standard, C9:0, to correct for losses of medium chain fatty acids (MCFA: C8:0, C10:0, C12:0) during the preparative phase. The pattern obtained was correlated with that of human milk (HM) or 67 kcal/dl formulas (F1 or F2) fed ad libitum from birth to 3 groups of infants (A,B,C). Group A consisted of 8 infants with a mean age (X̄±SD) of 75±29d and weight of 5.3±1.6 kg. Corresponding figures for group B comprising 7 infants, were 63±32d and 4.9±1.7 kg, while for the 7 subjects of group C they were 50±15d and 4.1±0.9kg. % of total FA:
These data show in ADIP a surprisingly large % of MCFA, linearly related (p<0.05) with the dietary intake of C10:0 and C12:0. Since this relationship did not hold for C8:0, it is suggested that C8:0 may be more completely oxidized. The metabolic fate of MCFA stored in ADIP needs to be explored.
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Sarda, P., Lepage, G. & Chessex, P. STORAGE OF MEDIUM CHAIN TRIGLYCERIDES (MCT) IN ADIPOSE TISSUE OF FORMULA FED INFANTS. Pediatr Res 18 (Suppl 4), 211 (1984). https://doi.org/10.1203/00006450-198404001-00707
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DOI: https://doi.org/10.1203/00006450-198404001-00707