Abstract
We studied the relationship between Estrone (E1), Estrone sulfate (E1S), Estradiol (E2) and androstenedione (Δ4) concs. in 32 children and adolescents with 21-OH def. adrenal hyperplasia (CAH). Concs. were measured in 23 normal prepubertal children, 8 normal adolescent males, and a pop. of normal adult males. There was a sig. (p<.01) correlation coefficient between E1, E1S, or E2 and Δ4 in subjects with androgen hormone excess. CAH patients were divided into 2 groups: I. prepubertal male and female children in good metabolic control based upon Δ4 conc. and II. adolescent males in good control and compared with previously described control groups.
The correlation of the estrogen profile and Δ4 in patients with adrenal androgen excess may reflect peripheral aromatization of Δ4 to E1 rather than increased adrenal secretion of E1. The sig. elevated conc. of E1, E1S, and E2 in CAH patients, despite good metabolic control, is surprising. Increased conc. of these hormones during the prepubertal years may in part explain alterations in pituitary gonadal function in older patients.
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Gutai, J., Watson, D. & Reiter, E. HYPERESTROGENISM IN CHILDREN WITH CAH: PERSISTENCE DESPITE GOOD CONTROL. Pediatr Res 18 (Suppl 4), 168 (1984). https://doi.org/10.1203/00006450-198404001-00451
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DOI: https://doi.org/10.1203/00006450-198404001-00451