Abstract
Hypoxemia has been reported to induce a decrease or an increase in renal function depending on various factors. This study assessed some hemodynamic and renal functions in hypoxemic neonatal pigs maintained at a normal PaC02. These results were compared with those of a similar study (Rowe, M.I., Strauss, J.; Pediatr. Res. 7:411/183, 1973) in which PaCO2 and PaO2 were decreased. Eleven piglets anesthetized with pentobarbital and mechanically ventilated were studied for a control period of 60 min. at a mean PaO2 of 76.1 (range 60-96) mmHg and after 60 min. ventilation with 10-12% 02 to attain a mean PaO2 of 33.4 (range 24-51) mmHg. The following increases were documented after 60 min. of hypoxemia; cardiac output, from 0.72 to 0.85 L/min; mean arterial blood pressure from 102.5 to 117 mmHg; urine volume from 0.027 to 0.063 ml/min/kg. Arterial blood pH decreased from 7.450 to 7.392. All changes were significant at p <0.05. These urinary results are similar to those obtained in piglets under Ketamine anesthesia, breathing spontaneously 10% 02, and whose PaC02 decreased markedly but whose cardiovascular variables were unchanged. It is concluded that hypoxemia induces a diuresis and natriuresis in piglets independent of changes in PaCO2, cardiac output or mean arterial blood pressure.
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Strauss, J., Daniel, S., Dickstein, P. et al. RENAL-HEMODYNAMIC CHANGES IN HYPOXEMIC NORMOCARBIC PIGLETS. Pediatr Res 18 (Suppl 4), 146 (1984). https://doi.org/10.1203/00006450-198404001-00317
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DOI: https://doi.org/10.1203/00006450-198404001-00317