Abstract
3 groups were studied. Group I: 20 patients who had been off treatment for acute lymphatic leukemia for at least 2 years. All patients had received prophylactic CI of 1800-2400 rads. Group II: 11 patients studied at least 2 yrs. after CI (dose 4000-5000 rads) for brain tumors not involving hypothalamic-pituitary area. - Oestradiol and testosterone (T) levels and T/SHBG ratio were in the normal range in group I, II. Basal and peak FSH levels after LH-RH were reduced in pubertal girls and prepubertal boys of group I and in pubertal girls of group II. Basal LH levels were lower in pubertal boys and LH peak was blunted in pubertal girls of group II. There was no significant difference in basal and TRH-stimulated prolactin, TBG, T4, T3 levels and T4/TBG ratios between group I, II and normal controls. Basal TSH was impaired in group II. Group I and II patients showed decreased basal and peak GH levels following insulin-hypoglycemia (IH). After arginine infusion (AI) lower peak GH values were found in group II. A decrement in basal and peak ACTH levels after IH, lysinevasopressin (LVP) and in circadian cortisols levels was found in group I, II. Following IH peak cortisol levels were reduced in group I and II, basal and LVP-induced peak cortisol values were decreased in group I. An increase in basal and peak insulin levels after AI was found in group I and in peak insulin values in group II. Group III: 4.9 yrs. after treatment for acute leukemia adult height was measured in 37 patients: height SDS was + 0.68 ± 1.2.
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Stahnke, N., Haupt, P., Willig, R. et al. Endocrine Function after Cranial Irradiation (CI). Pediatr Res 18, 1228 (1984). https://doi.org/10.1203/00006450-198411000-00165
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DOI: https://doi.org/10.1203/00006450-198411000-00165