Abstract
NaKATPase activity is low in the immature rat colon and increases till the 40th postnatal day. Studies from this laboratory have shown that immature renal tubular cells are more sensitive to the inductive effect of adrenocortical hormones on NaKATPase activity than mature cells. The aim of this study has been to examine whether endogenous fluctuations of aldosterone (Aldo) and/or corticosterone (CS) induced by changes in sodium balance can precociously increase NaKATPase activity in the immature colon. Young and adult rats were therefore given a normal (C) or low sodium (E) diet for 4 days and studied at the age of 20 and 40 days, respectively.
The effect of NaKATPase increase in 20 days secondary hyperaldo rats was evaluated using in vivo perfusion of colon. Net Na-absorption increased from control value 190 ± 91 μmol/min/dry g colon to 428.5 ± 97.2 (p < 0.05) and net fluid absorption increased from 1.02 ± 0.67 μl/min/dry g colon to 2.64 ± 0.75 (p < 0.05). These data indicate that aldosterone increases NaKATPase activity in proximal and distal colon, stimulates net sodium and water transport in large intestine and that the immature large intestine is more sensitive to aldosterone stimulation.
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Finkel, Y., Aperia, A. Importance of adrenocortical hormones for maturation of colonic NaKATPase activity. Pediatr Res 18, 797 (1984). https://doi.org/10.1203/00006450-198408000-00038
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DOI: https://doi.org/10.1203/00006450-198408000-00038