Abstract
Vent. response to CO2 was studied in 4 infants with BPD (Gr.l) (mean±S.D. B.W. 2070±501 gms; G.A. 31.6±2.3 wks), 3 infants shortly recovered from BPD (Gr.II)(normal blood gases and X-ray) (B.W. 1920±550 gms; G.A. 30.6±2 wks) and 4 normal control (Gr. 111)(1901±20 gms; G.A. 31.5±2.2 wks). To avoid hypoxia, all infants were given 70% O2 during the study. Tidal volume (VT), R.R, dynamic Compliance (CL), minutes ventilation (Vmin),TcPCO2 were all measured while the infant was breathing 0.03%, 1%, 2%, 3% and 3.5% CO2 for 2 min. There was no sign. difference in RR, CL,VT, PO2,PCO2 between Gr.II and Gr.III prior to study (RR:59±12 vs 57±8; CL 2.9±0.4 vs 3.7±0.8 ml/cmH2O/Kg; VT 8.7±1.1 vs 9.5 ±1.9 ml/Kg; PO2 38±4 vs 42±3 mmHg; PCO2 44±3 vs 40±2 mmHg) but infants in Gr.I had higher RR(74±15) and PCO2 (58±7 mmHg) and lower CL (1.7±0.6) and VT (6.5±1.8) as compared to Gr.II and III. (p <.05).
Compared with base line values within the group, infants in Gr. III had sign. increase in VT and Vmin. following breathing 2%,3%, 3.5% CO2; this was not seen in Gr.I and Gr.LL. The RR and CL remained unchanged in all groups during study. This study suggests that infants with BPD have less vent. response to CO2 as compared to normal infants.
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Yeh, T., Patel, H., Jain, R. et al. POOR VENTILATORY RESPONSE TO CO2 IN INFANTS WITH BRON CHOPULMONARY DYSPLASIA (BPD). Pediatr Res 18 (Suppl 4), 401 (1984). https://doi.org/10.1203/00006450-198404001-01847
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DOI: https://doi.org/10.1203/00006450-198404001-01847