Abstract
Perinatal asphyxia and intracranial hemorrhage are known to be major determinants of neurodevelopmental outcome in VLBW neonates, but specific and accurate predictors are not well established. Recent investigations have indicated that serum creatine kinase isoenzyme BB (CK-BB) levels are associated with outcome.
In this prospective study serum samples were obtained at 24 ± 4 hours in 83 preterm infants ≤ 32 weeks gestation. Cord blood was also available for analysis in 38 of them. Total CK and CK-BB by electrophoresis were determined on each of the samples. Mortality, cranial ultrasound scores on days 1 and 3, the presence of seizures within the first 2 weeks, abnormal neurological status (Sarnat Score) during the first 2 weeks, Parmalee neurological exam score at the time of discharge, and the presence of hydrocephalus were measured as short-term outcomes.
Using a non-parametric test for association (Kendall's tau), no associations were found between CK-BB values in either cord blood or 24 hour samples and any of the above parameters. Thus, CK-BB is not associated with short-term neurological status. Follow-up is underway to evaluate whether CK-BB may predict long-term neurodevelopmental outcome.
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Wimmer, J., Saldanha, R., Engelke, S. et al. BRAIN SPECIFIC CREATINE KINASE IS NOT ASSOCIATED WITH SHORT-TERM NEUROLOGICAL OUTCOME IN VLBW INFANTS. Pediatr Res 18 (Suppl 4), 384 (1984). https://doi.org/10.1203/00006450-198404001-01747
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DOI: https://doi.org/10.1203/00006450-198404001-01747