Abstract
Studies from our laboratories have demonstrated that the rate of renal Pi reabsorption is significantly greater in the newborn than in the adult guinea pig. In order to determine the location of this enhanced reabsorption along the nephron, micropuncture experiments were performed on euvolemic, non-fasted guinea pigs, 5-14 days and 42-49 days of age, maintained on standard guinea pig chow diet (0.76% Pi). Inulin concentrations were determined by the method of Viet, while Pi concentrations were measured by electron probe analysis*.
Maximal TRPi was reached in both age groups at a TF/Pin of 1.5. The results demonstrate that the proximal as well as the distal segments of the renal tubule contribute to the enhanced reabsorption of Pi characteristic of the growing subject, and that most of the reabsorption is achieved in the newborn, like in the adult, in the early segment of the proximal convoluted tubule.
*Performed at the National Biotechnology Resource in Electron Probe Microanalysis, Harvard Medical School, Boston, Mass. (C. Lechene, Director).
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Kaskel, F., Kumar, A., Feld, L. et al. RENAL TUBULAR REABSORPTION OF PHOSPHATE (Pi) DURING DEVELOPMENT. Pediatr Res 18 (Suppl 4), 370 (1984). https://doi.org/10.1203/00006450-198404001-01665
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DOI: https://doi.org/10.1203/00006450-198404001-01665