Abstract
We assessed the way duration of exposure to hyperoxia affects number and muscularity of pulmonary arteries and alveolar growth and which features show potential for recovery.Thirty-nine 10 day old Sprague-Dawley rats were used;19/39 exposed to normobaric hyperoxia(↑F102.8) and 20 age matched controls(C);of 19 experimental animals,6 were exposed for 2 wks. only (↑F102-2),6 allowed to "recover" in room air for 2 wks.(↑F102-2+RA) and 7 exposed for a further 2 wks.(↑F102-4). At post mortem, ventricular weights(RV,LV) were obtained and lungs injected and fixed inflated for lung volumes(Vol) and morphometric analysis of arteries per 100 alveoli (A/100a),alveoli/mm2,medial wall thickness of muscular arteries (%WT) and extension of muscle into peripheral arteries(%Ext).
Increasing duration of hyperoxia causes failure to thrive and progressively severe reduction in arterial number and extension of muscle. During "recovery" there is compensatory increase on arterial number but a large lung results from growth of a normal number of large alveoli; also despite return to nomoxia, extension of muscle progresses and medial hypertrophy is apparent.
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Wilson, W., Mullea, M., Olley, P. et al. HYPEROXIA INDUCED PULMONARY VASCULAR AND LUNG ABNORMALITIES IN YOUNG RATS AND POTENTIAL FOR RECOVERY. Pediatr Res 18 (Suppl 4), 341 (1984). https://doi.org/10.1203/00006450-198404001-01490
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DOI: https://doi.org/10.1203/00006450-198404001-01490