Abstract
16 premature infants born between 1978 and 1982 were diagnosed as having systemic candidiasis and treated with Amphotericin B. 5 infants died and one was lost to follow up. The remaining 10 had a mean gestational age of 27 weeks and a mean birthweight of 900 grams. Candidiasis was diagnosed at a mean age of 11 weeks. 3 infants had meningitis. All were treated with total mean doses of 21.1 mg Amphotericin B and 2.3 gm 5FC for an average of 27.7 days. Complications of therapy included thrombocytopenia (2) and transient renal abnormalities (8). The 10 survivors were matched for age, race, sex, gestational age, birthweight, and family socioeconomic status with 10 control infants and re-evaluated at a mean age of 21 months. Development was measured with Bayley Scales and compared using a paired t test. Mean mental and motor scores were 92.6±21.2/91±22.2 for study infants and 89.8±12.5 /86.5±12.1 for controls (p=NS).
This study suggests that neonatal candidiasis should be promptly treated because outcome may be good.
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Golden, N., Richardson, J., McMillan, P. et al. OUTCOME OF NEONATAL SYSTEMIC CANDIDIASIS. Pediatr Res 18 (Suppl 4), 324 (1984). https://doi.org/10.1203/00006450-198404001-01385
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DOI: https://doi.org/10.1203/00006450-198404001-01385