Abstract
Serum salicylate levels ([ASA]) were obtained at admission from 172 cases of Reye's Syndrome (RS), 130 of whom were biopsy proven. Shown are [ASA] for biopsy proven cases, by clinical grade, and age matched, community matched, sick and well control children.
Liver biopsy ultrastructure of RS pts with high [ASA] (≥20mg/dl) was not different from that of comparably ill pts with low [ASA] (≤2mg/dl); both differed greatly from that of a non-RS pt with acute ASA intoxication (ASA 66 mg/dl). There is no correlation between clinical grade, mean [ASA] or outcome; but RS pts had 10× higher [ASA] than controls. We propose the higher [ASA] in RS pts are due to liver injury and reduced metabolism rather than the cause of the injury.
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Partin, J., Partin, J., Schubert, W. et al. 619 SALICYLATES AND REYE'S SYNDROME. Pediatr Res 15 (Suppl 4), 543 (1981). https://doi.org/10.1203/00006450-198104001-00632
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DOI: https://doi.org/10.1203/00006450-198104001-00632