Abstract
The etiology of food protein-induced enterocolitis is unknown, but immunologic mechanisms have been suspected. Class specific serum soy antibody response was determined (by ELISA) in 11 infants age 3 to 7 months with a history of enterocolitis, who were undergoing a diagnostic food challenge at least 1 month after recovery. Infants received a single oral dose of antigen (0.6 gm/kg) and challenges were evaluated as previously described (J Ped 93:533). The mean baseline(B) and 6 week followup(F) antibodies to the whole soy protein are shown below, expressed as a percentage of a standard reference pool.
Infants with POS response had significantly higher baseline and followup IgG and IgA antibodies (p<.01, ANOVA on log transformed data). IgM antibodies fell in 6 of 7 infants with POS response but rose in those with NEG response (p<.002). The two groups did not differ with respect to age, time since last exposure to soy, or serum immunoglobulin levels. Differences in class specific antibody responses in the two groups suggests either enhanced mucosal penetration of antigen or differences in regulation of immune responses in soy-induced enterocolitis patients.
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Mcdonald, P., Powell, G., Goldblum, R. et al. 599 FOOD PROTEIN-INDUCED ENTEROCOLITIS: ALTERED ANTIBODY RESPONSE TO ORAL ANTIGEN CHALLENGE. Pediatr Res 15 (Suppl 4), 540 (1981). https://doi.org/10.1203/00006450-198104001-00612
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DOI: https://doi.org/10.1203/00006450-198104001-00612