Abstract
Growth hormone deficiency has been reported in 10-20% of Russell-Silver dwarfs. Two siblings with all the classical features of Russell-Silver Syndrome were low in growth hormone (insulinarginine stimulation test), and blood and hair zinc (Zn). They received 50 mg elemental Zn orally each day for 2 months and 50 mg weekly for 4 more months. Growth hormone and Zn determinations were repeated at 6 months:
It appears there is a direct relationship between the growth hormone response and Zn nutritional status. We have data indicating that growth hormone therapy increases hair Zn and decreases urinary Zn in children with growth hormone deficiency. These two children provide new data indicating that there are patients whose growth hormone production is affected by their Zn nutritional status.
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Ghavami-Maibodi, Z., Castro-Magana, M., Clejan, S. et al. 427 IMPROVING GROWTH HORMONE RESPONSE WITH ORAL ZING THERAPY IN RUSSELL-SILVER DWARFISM. Pediatr Res 15 (Suppl 4), 511 (1981). https://doi.org/10.1203/00006450-198104001-00438
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DOI: https://doi.org/10.1203/00006450-198104001-00438