Abstract
Both GH and a variety of immunostimulants have been shown to inhibit MFO activity. We wished to determine whether the action of Cp is mediated by GH and, if not, whether there is evidence of a common mechanism. Cp in a single dose of 20 mg/kg resulted in increased r (rat) GH levels in trunk blood 96 hours later (96±27 vs 24±2 ng/ml; p<0.05) and in pituitary glands (136±16 vs 91±8 mcg/mg; p<0.05). Frequent sampling studies showed that spontaneous rGH secretion was significantly greater 24 hr after Cp. However, hypophysectomized male and female rats still responded to Cp with significant decreases in aminopyrine-N-demethylase and aniline hydroxylase activities in liver microsomes and with a fall in cytochrome P450 content. In intact animals, rGH 25μg bid for 3 days or Cp 20 mg/kg produced equal depression of MFO function. However, in contrast to hypophysectomy, splenectomy abolished the ability of the animal to depress MFO function in response to Cp.
Conclusions: 1) Cp increases rGH synthesis and secretion, 2) the pituitary is not required for suppression of MFO by Cp, 3) Cp and rGH depress MFO to a similar degree and 4) the spleen is required for the Cp effect on MFO.
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Redmond, G., Berger, W. & Soyka, L. 362 INHIBITION OF MIXED FUNCTION OXIDASES (MFO) BY GROWTH HORMONE (GH) AND BY THE IMMUNOSTIMULANT CORYNE-BACTERIUM PARVUM (Cp): EVIDENCE FOR A COMMON MECHANISM. Pediatr Res 15 (Suppl 4), 500 (1981). https://doi.org/10.1203/00006450-198104001-00373
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DOI: https://doi.org/10.1203/00006450-198104001-00373