Abstract
In view of the paucity of steady-state VPA pharmacokinetic data in children, we present the results from a study of 30 patients on this drug (doses of 15-46 mg/kg/day):
Cl and Vd were higher in those receiving phenytoin and/or phenobarbital; the lowest Cl were found in 4 patients on methsuximide. Cl was inversely related to age and t½ was age and sex dependent:
Peak and trough concentration ranges were 45 - 127 μg/ml and 13 - 101 μg/ml respectively; the variability in these concentrations emphasizes the need for specifying time of sampling in therapeutic monitoring. Our study also draws attention to (1)dependence of t½ on age and sex and (2) effect of other anticonvulsants and age on Cl of VPA. These data are of therapeutic import. This study was sponsored by White Cross Guild, MMSFI, and CHRF.
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Otten, N., Hall, K., Irvine-Meek, J. et al. 353 VALPROIC ACID (VPA): STEADY-STATE PHARMACOKINETICS IN PEDIATRIC PATIENTS WITH SEIZURES. Pediatr Res 15 (Suppl 4), 499 (1981). https://doi.org/10.1203/00006450-198104001-00364
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DOI: https://doi.org/10.1203/00006450-198104001-00364