Abstract
Shock produced by acute iron (Fe) poisoning is thought to be due to venous dilation with decreased ventricular filling. This study examined the effects of acute Fe++ on MCF. Heart rate(HR), mean blood pressure(BP), mean right atrial pressure(RAP), cardiac output(CO), strain gauge measurement of right ventricular force (RVF; % of time 0), and arterial pH were measured in open-chest rabbits. Animals were divided into 3 groups (N=7 in each group): 1)Control (no Fe); 2) Fe(200mg/kg administered into the duodenum); and 3)Fe(200mg/kg)plus NaHCO3 (9 meq/hr, IV). Variables did not differ among the groups at time 0. Results (mean ± SEM) 30 minutes after Fe administration are shown below.
Within 30 minutes, Fe produced a significant reduction in MCF as evidenced by decreased CO and RVF, with no reduction in filling pressure (RAP). Fe produced myocardial depression independent of acidosis. The direct depressant effect of Fe on MCF could be responsible, in part, for the shock seen in acute Fe ingestion. These findings may provide the basis for new approaches to the treatment of shock in Fe poisoning.
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Artman, M., Olson, R. & Boerth, R. 310 DEPRESSION OF MYOCARDIAL CONTRACTILE FUNCTION (MCF) IN ACUTE JRON POISONING. Pediatr Res 15 (Suppl 4), 491 (1981). https://doi.org/10.1203/00006450-198104001-00321
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DOI: https://doi.org/10.1203/00006450-198104001-00321