Abstract
Seven children (aged 3½-15 years) consecutively admitted, with the diagnosis of Reye's were evaluated for cardiac dysfunction by echocardiography, EKG and serum enzymes. The preceding viral disease was varicella in 6 and influenza A in 1. Two died and had microscopic myocarditis. All had normal LD1 and CPK-MB isoenzymes.
In addition, a retrospective study of 17 cases of fatal varicella demonstrated microscopic myocarditis in 11. In none of the 11 children was myocarditis recognized prior to death. This study suggests that the heart is a significant target organ in Reye's syndrome, particularly when preceded by varicella, and its function must be considered in the care of these children.
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Noren, G., Tobin, J., Staley, N. et al. 178 ASSOCIATION OF REYE'S SYNDROME AND CARDIOMYOPATHY. Pediatr Res 15 (Suppl 4), 469 (1981). https://doi.org/10.1203/00006450-198104001-00187
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DOI: https://doi.org/10.1203/00006450-198104001-00187