Abstract
A controlled trial of early closure of PDA with indomethacin versus closure of PDA after failure of medical management was performed in 24 very low birthweight infants with severe RDS requiring mechanical ventilation. End points in the study design were freedom from bronchopulmonary dysplasia and 6 month survival. No differences in birthweight, gestational age, Apgar scores, or age of first PDA diagnosis were found between the two groups. Infants undergoing early PDA closure (48.8±16.0 hrs) versus the control infants (167.4±162.7 hrs) had significantly reduced BPD (18.2 vs. 88.9% p<.0027) and greater survival (p<.0014) than infants undergoing PDA closure because of cardiopulmonary decompensation. Our data suggest that early intervention to eliminate adverse effects of the PDA can have greatest benefit if closure occurs before pulmonary damage, associated with congestive heart failure, pulmonary edema, and their effects on lung function, is beyond a state of physiologic repair. (Supp. by HD-13279).
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Merritt, T., Harris, J. & Roghmann, K. 170 EARLY CLOSURE OF THE PATENT DUCTUS ARTERIOSUS (PDA): A CONTROLLED STUDY. Pediatr Res 15 (Suppl 4), 468 (1981). https://doi.org/10.1203/00006450-198104001-00179
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-00179