Abstract
Serial aortic contrast echocardiographic studies (ACE) and differential blood gases were performed on 164 neonates with respiratory distress (149 preterm, 10 fullterm, BW=1569±421) to determine the incidence and natural history of PDA and its influence on respiratory disease. Infants were divided into three groups: (A) Spontaneous closure (SC)≤24 hrs.(B) SC≤72 hrs. (C) PDA persisting≥72 hrs. 5 neonates with open PDA died prior to 72 hrs Results are summarized in the following table:
While the proportion of infants ≤ 1200 gm was greatest in C, differences in outcome were not related to birth weight. The documentation of PDA closure by ACE generally preceded clinical improvement in respiratory status and appeared to represent functional closure. Spontaneous closure of PDA prior to 72 hrs. was a good prognostic sign whereas persistence of PDA after 72 hrs. was associated with a protracted course. These data suggest that early intervention (≤ 72 hrs.) for PDA may be helpful in the management of neonates with severe respiratory disease.
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Dudell, G., James, L. & Gersony, W. 128 THE ROLE OF PATENT DUCTUS ARTERIOSUS (PDA)IN THE NEONATE WITH SEVERE RESPIRATORY DISEASE: A PROSPECTIVE STUDY. Pediatr Res 15 (Suppl 4), 461 (1981). https://doi.org/10.1203/00006450-198104001-00137
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DOI: https://doi.org/10.1203/00006450-198104001-00137