Abstract
Previous studies have demonstrated that the phenothiazine anti-psychotic drug PER blocks r (rat) GH secretion (Redmond, Neuroendocrinol 30:243, 1980) and retards growth (Redmond and Hirshman, Ped Pharmacol, in press). In order to determine whether the diminished rGH secretion was causally related to the growth retardation, an experiment was performed in which rGH replacement was given with PER. Raw results in male Sprague-Dawley rats were as follows:
When data was transformed using covariate analysis to adjust for food intake, there was significant restoration by rGH of growth in both weight and length of PER treated rats.
Conclusion: Inhibition of rGH secretion is at least one of the mechanisms by which PER impairs growth.
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Redmond, G., Soncrant, T. & Soyka, L. 89 ROLE OF GROWTH HORMONE (GH) IN THE GROWTH RETARDATION PRODUCED BY PERPHENAZINE (PER). Pediatr Res 15 (Suppl 4), 454 (1981). https://doi.org/10.1203/00006450-198104001-00098
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DOI: https://doi.org/10.1203/00006450-198104001-00098