Abstract
Rubella serology (R-HAI) on 129 adolescents was performed and the response to revaccination of seronegative (<1:8) and low titer (1:8-1:32) subjects was determined (R-IgM, R-IgG).
Seventeen percent (18/108) of adolescents with documented rubella vaccination (a mean of 8.3 years before) had no detectable (R-HAI) rubella antibody.
Each of 9 previously immunized but seronegative patients developed a R-IgG response following rubella revaccination and no R-IgM response was detected. Each of 12 previously immunized but low titer (1:8-1:32) patients developed a R-IgG response following rubella vaccination and no R-IgM was detected. In contrast, two seronegative subjects who had never previously received vaccine developed R-IgM in their sera two weeks following immunization.
The presence of a secondary immune response (R-IgG) despite absence of antibody detectable by R-HAI in previously immunized patients suggests that the R-HAI is an inadequate screening tool. Reimmunization with RA27/3 of 10-11 year old females is recommended until a more satisfactory serologic test is available.
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Butler, A., Scott, R., Schydlower, M. et al. 4 RUBELLA SUSCEPTIBILITY IN AN ADOLESCENT POPULATION: HOW REAL IS THE RISK?. Pediatr Res 15 (Suppl 4), 440 (1981). https://doi.org/10.1203/00006450-198104001-00013
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DOI: https://doi.org/10.1203/00006450-198104001-00013