Abstract
The neonatal screening of hypothyroidism started in France in 1975 in a few districts, then progressively extented to the whole country In 1980 the testing rate is 96.9%. 1.324.000 infants have been tested and 320 hypothyroidism detected. The incidence is 1/3200. Thyroid scanner (Tc 99 or I 123) revealed ectopia in 54%, athyreosis in 30% and gland in normal place in 16%. TSH levels are above 100 μU/ml in most cases. The control of T4 was made in 167 cases. T4 levels is 1,27±0,8 μg/dl in athyreosis and 3,9±2,6 in ectopia (p<0,001). In 23 ectopia the T4 levels is normal, above 5μg/dl. A study of clinical score and bone maturation took place in 188 hypothyroidism. The clinical score is 2,9±1 in athyreosis and 1,7±1,2 in ectopia (p<0,001). We found a correlation between clinical score, T4 levels and T3 levels (p<0,02). The epiphysis area (Knee) is 6,4 ± 10 mm2 in athyreosis and 20,6±11 in ectnpia (p<0,001). There is a correlation between epiphysis area, clinical score, T4 levels and T3 levels (p<0,05). Psycho-motor development (Brunet-Lezine Test), with a 3 years survey, was only studied in 30 hypothyroidism followed in Midi-Pyréoées district. The global QD is respectivaly 101±9, 96±8 and 99±10 at the age of 6, 18 and 36 months. Partial QD are normal at 6 months but langage and sociability drop at 88±12 at months, and a difference is found between athyreosis and ectopia for all partial QD at this age. These results allow us to find the differences known between ectopia and athyreosis in spite on early treatment.
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Rochiccioli, P., Farriaux, J., Briard, M. et al. Neonatal screening of hypothyroidism in France, Results of screening: 1.300.000 infants. Pediatr Res 15, 1538 (1981). https://doi.org/10.1203/00006450-198112000-00019
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DOI: https://doi.org/10.1203/00006450-198112000-00019